Heart Failure: Molecules, Mechanisms And Therapeutic Targets (Novartis Foundation Symposia)

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Heart failure is the main cause of death and disability in theindustrialized world. There is a major need for novel therapeuticsfor prevention and reversal of cardiac pathology associated withheart failure and cardiac enlargement. Over recent years, dramaticprogress has been made in unravelling the cellular circuitryinvolved in cardiac failure, as well as in normal cardiac growth,development and a...

Series: Novartis Foundation Symposia (Book 274)
Hardcover: 302 pages
Publisher: Wiley; 1 edition (September 11, 2006)
Language: English
ISBN-10: 0470015977
ISBN-13: 978-0470015971
Product Dimensions: 6.2 x 0.8 x 9.2 inches
Amazon Rank: 13278668
Format: PDF ePub Text djvu ebook

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his work has revealed new andunexpected therapeutic targets in the heart. In addition, advancesin understanding the role of stem cells in cardiac physiology havesuggested strategies for cardiac repair and regeneration oncethought impossible. This book describes the work of leading investigators studyingthe basic mechanisms of cardiac growth, function and dysfunction.There are also exciting contributions from researchers developingnovel therapeutic strategies for cardiac disease. The uniquefeature is the discussions amongst the contributors, which alwaysreturn to the same basic problem: how can new data from biologicalstudies be used to design novel therapies for the treatment ofcardiac dysfunction following myocardial infarction, hypertensionand other disorders?With its strong emphasis on translational research, this bookwill appeal to both scientists and clinicians interested indiminishing the impact of the current epidemic of cardiacdiseases.